Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia

Background. Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia. Methods. Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies. The distribution of genotypes for −1607 1G/2G MMP1, −735 C/T MMP2, −1306 C/T MMP2, −1171 5A/6A MMP3, and −1562C/T MMP9 polymorphisms was determined by RFLP-PCR. Results. The occurrence of 1G/1G MMP1 or 5A/5A MMP3 genotype in the mother or 1G/1G MMP1 or 5A/6A MMP3 genotype in the child is associated with preeclampsia development. Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A MMP3 genotypes by over 4.5 times. No association between the carriage of studied MMP2 or MMP9 polymorphisms and the predisposition to preeclampsia was found. Conclusion. The maternal 1G/1G MMP1 and 5A/5A MMP3 and fetal 1G/1G MMP1 and 5A/6A MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together

MVC Model, Struts Framework and File upload Issues in Web Applications Based on J2EE Platform

This paper describes the web application based on the J2EE platform indicating the MVC model, Struts framework and file upload issues. The development of internet technology and the will to standardize the mechanisms used in implementation of internet applications was the basis background for the development of J2EE platform. The project of International Office TUL internet service is an application based on the above mentioned environment. The specification of the project is closely connected with the activities and needs of the staff of the International Office. The article presents the use of MVC model on J2EE platform on an example of open source Apache/Tomcat application server and the database management system MySql

EXAMPLES OF MEDICAL SOFTWARE AND HARDWARE EXPERT SYSTEMS FOR DYSFUNCTION ANALYSIS AND TREATMENT

Paper present the recent research in DMCS. The medical and biometric research projects are presented. One of the key element is an image acquisition and processing. The paper presents research of diagnostic application of voice analysis for stroke patients with speech dysfunction, as well as the method for diagnosing and monitoring the effectiveness of medical rehabilitation of patients with dysfunction of the cervical spine. Then the method for sudden cardiac death risk stratification is elaborated

RECENT RESEARCH IN VLSI, MEMS AND POWER DEVICES WITH PRACTICAL APPLICATION TO THE ITER AND DREAM PROJECTS

Several MEMS (Micro Electro-Mechanical Systems) devices have been analysed and simulated. The new proposed model of SiC MPS (Merged PIN-Schottky) diodes is in full agreement with the real MPS devices. The real size DLL (Dynamic Lattice Liquid) simulator as well as the research on modelling and simulation of modern VLSI devices with practical applications have been presented. In the basis of experience in the field of ATCA (Advanced Telecommunications Computing Architecture) based systems a proof-of-concept DAQ (data acquisition) system for ITER (International Thermonuclear Experimental Reactor) have been proposed

Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age

This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR–RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups

Application of the SIP Protocol in Telecommunication, Based on a Image Transmitting Application

Abstract -This paper presents the idea of convergence of the IT and telecommunication worlds, based on an example application. The program has been developed in Microsoft Visual Web Developer 2008 environment. As one of the aims the possibilities of convergence are being described. The example application allows users to communicate by video conference using soft phone on one side and WWW browser on the other, via Internet connection

Towards uniformity of rotational events recording : initial data from common test engaging more than 40 sensors including a wide number of fiber-optic rotational seismometers

Rotational seismology is one of the fastest developing fields of science nowadays with strongly recognized significance. Capability of monitoring rotational ground motions represents a crucial aspect of improving civil safety and efficiency of seismological data gathering. The correct sensing network selection is very important for reliable data acquisition. This paper presents initial data obtained during the international research study which has involved more than 40 various rotational sensors collected in one place. The key novelty of this experiment was the possibility to compare data gathered by completely different rotational sensors during artificially generated ground vibrations. Authors collected data by four interferometric optical fiber sensors, Fiber-Optic System for Rotational Events & Phenomena Monitoring (FOSREM), which are mobile rotational seismographs with a wide measuring range from 10⁻⁷ rad/s up to even few rad/s, sensitive only to the rotational component of the ground movement. Presented experimental results show that FOSREMs are competitive in rotational events recording compared with the state-of-the-art rotational sensors but their operation still should be improved

Investigation of rotational motion in a reinforced concrete frame construction by a fiber optic gyroscope

This paper deals with an issue of a rotational motion impact on a construction and presents civil engineering applications of a fiber optic rotational seismograph named Fiber-Optic System for Rotational Events & Phenomena Monitoring. It has been designed for a long- term building monitoring and structural rotations’ recording. It is based on the Sagnac effect which enables to detect one-axis rotational motion in a direct way and without any reference system. It enables to detect a rotation component in the wide range of a signal amplitude from 10-8 rad/s to 10 rad/s, as well as a frequency from DC to 1000 Hz. Data presented in this paper show the behavior of a reinforced concrete frame construction on different floors. Several measurements were carried out by placing the applied sensor on different floor levels of a building. The laboratory and in-situ measurements confirmed that Fiber-Optic System for Rotational Events & Phenomena Monitoring is an accurate and suitable device for applications in civil engineering